As an important component of the extracellular matrix, hyaluronic acid fills soft tissue depressions and supports contours through its high hydrophilicity and viscoelasticity, while stimulating collagen regeneration to enhance skin elasticity. In addition, its biocompatibility and degradability enable it to be safely used for maxillofacial volume filling and fine line improvement, and it has been widely applied in the field of maxillofacial beauty. This study summarizes the chemical structure, molecular weight, biocompatibility and physical properties of hyaluronic acid, and reviews its application in maxillofacial cosmetic injection, injection techniques and operational key points, treatment safety, and risk prevention and control points, in order to provide reference for clinical treatment.