Objective To analyze the effect of orthodontics-assisted oral implant restoration on dental function and aesthetic effect in patients with dentition defect complicated with malocclusion. Methods A total of 90 patients with dentition defect complicated with malocclusion admitted to our hospital from January 2023 to December 2024 were selected as the research subjects, and they were divided into the control group and the study group by the random number table method, with 45 patients in each group. The control group received oral implant restoration, and the study group received oral implant restoration combined with orthodontics treatment. The treatment effect, dental function, oral health status and aesthetic effect were compared between the two groups. Results The total effective rate of treatment in the study group (97.78%) was higher than that in the control group (82.22%) (P <0.05). The scores of masticatory function, language function and swallowing function in the two groups after treatment were higher than those before treatment, and those in the study group were higher than those in the control group (P <0.05). The scores of plaque index and debris index in the two groups after treatment were lower than those before treatment, and those in the study group were lower than those in the control group (P <0.05). The proportions of good posterior tooth occlusion, neat dental arrangement, and good anterior tooth overjet/overbite in the study group were higher than those in the control group (P <0.05). Conclusion The orthodontics-assisted oral implant restoration plan for patients with dentition defect complicated with malocclusion can effectively improve dental function and enhance masticatory function. At the same time, it can also improve dental aesthetic degree and enhance patients' oral health level.