Objective To explore the effect of oral implant restoration on periodontal health indicators in patients with dentition defect complicated with periodontitis. Methods A total of 64 patients with dentition defect complicated with periodontitis admitted to Saihan District Zhimei Dental Clinic from April 2024 to March 2025 were selected as the research subjects, and they were divided into the control group and the experimental group by the random number table method, with 32 patients in each group. The control group received conventional restoration treatment, and the experimental group received oral implant restoration treatment. The periodontal health indicators, inflammatory factor levels and masticatory function were compared between the two groups. Results After treatment, the mSBI, PIS, PD, PLI and CAL in the experimental group were lower than those in the control group (P <0.05). After treatment, the levels of IL-2 and IL-8 in the experimental group were lower than those in the control group (P <0.05). After treatment, the occlusal force [(125.72±9.25)lbs] and masticatory efficiency [(76.12±6.42)%] in the experimental group were higher than those in the control group [(106.23±6.72)lbs, (67.21±6.28)%] (P <0.05). Conclusion Oral implant restoration has a definite effect in the treatment of patients with dentition defect complicated with periodontitis. It helps to reduce the inflammatory response of periodontal tissues and improve periodontal health. At the same time, it can promote the recovery of patients' masticatory function, with high clinical application value.