Objective To analyze the effect of topical furosemide-digoxin mixed cream in the treatment of verruca vulgaris and its influence on patients' skin healing outcome. Methods A total of 60 patients with verruca vulgaris admitted to the Dermatology Outpatient Department of Liyang People's Hospital from March to October 2024 were selected as the research subjects, and they were divided into group A, group B and group C by the random number table method, with 20 patients in each group. Group A was given liquid nitrogen cryotherapy, group B was given CO2 fractional laser therapy, and group C was given topical furosemide-digoxin mixed cream. The treatment effect, skin healing outcome, adverse reaction rate, number of warts and recurrence rate were compared among the three groups. Results The total effective rate of treatment in group C (95.00%) was higher than that in group A (80.00%) and group B (90.00%) (P <0.05). The skin healing outcome in group C was better than those in group A and group B (P <0.05). The incidence of adverse reactions in group C was lower than that in group A (P <0.05). The number of warts in group C after treatment was less than that in group A and group B (P <0.05). There was no significant difference in recurrence rate among the three groups (P >0.05). Conclusion Topical furosemide-digoxin mixed cream has a good effect in the treatment of verruca vulgaris. Compared with liquid nitrogen cryotherapy and CO2 fractional laser therapy, it has better curative effect, can further optimize skin healing outcome, reduce the incidence of adverse reactions and decrease the number of warts.