Objective To explore the effect of Opus Plasma in the treatment of early scar. Methods A total of 30 patients with scar who received treatment in Liuzhou Worker's Hospital from May to September 2024 were selected, and they were divided into the control group and the observation group by the random number table method, with 15 patients in each group. Both groups received dye laser treatment to reduce redness and inhibit vascular dilation. The control group was treated with fractional carbon dioxide laser, and the observation group was treated with Opus Plasma. The scar appearance scores, pain scores and pruritus scores were compared between the two groups. Results At 1 and 3 months after treatment, the scores of scar color in the observation group were lower than those in the control group (P <0.05). At 3 months after treatment, the score of scar toughness in the observation group was lower than that in the control group (P <0.05). At 1 and 3 months after treatment, the VAS scores in the observation group were lower than those in the control group (P <0.05). At 3 months after treatment, the pruritus score in the observation group was lower than that in the control group(P <0.05). Conclusion The application effect of Opus Plasma in the treatment of early scar is definite, which can effectively improve scar color and toughness, and help to alleviate pain and pruritus symptoms. Compared with fractional carbon dioxide laser treatment, Opus Plasma treatment has better patient tolerance and comfortable experience, and is worthy of clinical application.