Objective To analyze the effect of high quality nursing intervention based on clinical nursing pathway on hand function recovery and scar improvement in patients with hand burn plastic surgery. Methods A total of 120 patients with hand burn who were treated in the Burn and Trauma Diagnosis and Treatment Center, Affiliated Hospital of Jiangnan University from January 2022 to December 2023 were selected as the research subjects. According to different nursing methods, they were divided into the control group (received routine nursing) and the study group (received high quality nursing intervention based on clinical nursing pathway), with 60 patients in each group. The hand function recovery, wound outcome time, scar improvement, and complication rate were compared between the two groups. Results After 6 mouths of intervention, the hand function recovery of the study group was better than that of the control group (P <0.05). After intervention, the wound outcome time of the study group was shorter than that of the control group (P <0.05). After intervention, the scar improvement of the study group was better than that of the control group (P <0.05). The incidence of complications in the study group was 0, which was lower than 6.67% in the control group (P <0.05). Conclusion The application of high quality nursing intervention based on clinical nursing pathway in patients with hand burn plastic surgery can not only effectively shorten the wound outcome time, promote the overall recovery of hand function, and reduce scar formation, but also has high safety.