Post-adolescent acne is a common clinical delayed-onset dermatosis, characterized by multiple inflammatory papules and nodules, which often occurs on the lower face. It is often accompanied by refractory pigmentation and scar formation, and the course of the disease is characterized by alternating periodic exacerbation and remission. Such visible skin lesions can cause significant psychological impact on patients in the critical period of self-identity. Patients are prone to social avoidance and develop stigma and self-stigmatization due to repeated treatment failure, and some patients even develop abnormal behaviors such as compulsive skin examination, thereby increasing the risk of anxiety and depression emotions. To address above psychological problems, targeted management measures need to be formulated, such as strengthening skin health knowledge education and introducing cognitive behavioral therapy, to intervene in anxiety and depression emotions and help patients smoothly pass through this special period. This paper begins with the current status of anxiety and depression emotions in patients with post-adolescent acne, and conducts an in-depth analysis of the origins and contributing factors of their psychological state. Through systematically combing the relevant literature, this paper further explores the mechanism of different genders, ages and disease severity on patients' mental health, in order to provide a theoretical reference for clinicians to carry out relevant research.