Traditional salicylic acid preparations have long faced with the dilemma of high concentrations irritate, low concentrations underperform, restricting their application in the treatment of acne and related dermatoses. The supramolecular salicylic acid antibacterial gel, based on supramolecular carrier technology, now offers a fresh route out of this impasse. This article systematically reviews the technological innovation and clinical application value of this preparation. In terms of technology, it focuses on analyzing the advantages of its pH-sensitive sustained-release system in balancing effective concentration and irritation, as well as the characteristics of broad-spectrum antibacterial activity and multi-target effects. In clinical practice, it summarizes the mechanism of action, efficacy evidence and treatment plan optimization strategies in diseases such as acne, rosacea, bacterial folliculitis and melasma, and discusses its application specifications, combined therapy and safety, so as to provide a theoretical basis and practical guidance for the clinical transformation of this preparation.