Objective To analyze the effect of instrument-based quantitative analysis and aesthetic evaluation method on facial soft tissue angles in patients undergoing invisible aligner orthodontic treatment. Methods A total of 160 patients with dento-maxillofacial deformity who received invisible aligner orthodontic treatment in Ma'anshan General Hospital of Ranger-Duree Healthcare from January 2021 to January 2023 were selected as the research subjects, and they were divided into the control group and the study group by the random number table method, with 80 patients in each group. Both groups were given invisible aligner orthodontic treatment. The control group adopted the manual facial contour measurement method, and the study group adopted the instrument-based quantitative analysis and aesthetic evaluation method on the basis of the control group. The facial soft tissue angles, aesthetic effects and aesthetic analysis time were compared between the two groups. Results After treatment, the nasal labial angle and mentolabial sulcus angle of the study group were better than those of the control group (P<0.05). The aesthetic effect score of the study group was higher than that of the control group (P<0.05). The measurement marking time, measurement time, result analysis time and report generation time of the study group were shorter than those of the control group (P<0.05). Conclusion The application of instrument-based quantitative analysis and aesthetic evaluation method in invisible orthodontic treatment can provide accurate soft tissue angle data for the adjustment of orthodontic parameters, which is helpful to restore the relevant angles of facial soft tissue, enhance aesthetic effect, and shorten the relevant aesthetic analysis time, and is worthy of clinical application.