Objective To analyze the effect of full incision minimally invasive double eyelid surgery on clinical indicators in patients undergoing double eyelid surgery. Methods A total of 120 patients who received double eyelid surgery in the Department of Plastic Surgery, the First People's Hospital of Guiyang from January 2023 to December 2024 were selected as the research subjects, and they were divided into the control group and the observation group according to different treatment methods, with 60 patients in each group. The control group was treated with traditional incision double eyelid surgery, and the observation group was treated with full incision minimally invasive double eyelid surgery. The clinical indicators, patient satisfaction and complications were compared between the two groups. Results The operation time and postoperative detumescence time of the observation group were shorter than those of the control group, and the intraoperative blood loss was less than that of the control group (P <0.05). The patient satisfaction of the observation group was 93.33%, which was higher than 76.67% of the control group (P <0.05). There was no significant difference in the incidence of complications between the two groups (P >0.05). Conclusion Compared with traditional incision double eyelid surgery, full incision minimally invasive double eyelid surgery has smaller trauma, shorter operation time, and faster postoperative recovery, which can effectively improve patient satisfaction. It is worthy of clinical application.