With the development of higher education, educational reform guided by the concept of Outcome-based Education (OBE) has been widely carried out around the world. Centering on the concept of OBE, this paper deeply explores the construction strategies and practical effects of the first-class course of Dental Materials. It designs curriculum objectives in a reverse manner, closely aligning with graduation requirements and professional needs, reconstructs teaching content by integrating cutting-edge knowledge and combining clinical cases, innovates teaching methods, such as adopting online-offline blended learning, casebased learning and group cooperative learning, and establishes a diversified assessment system to comprehensively assess students' learning outcomes and ability improvement.