Objective To explore the effect of orthodontics combined with implant restoration on dental function and aesthetic outcome in patients with dentition defect complicated with dento-maxillofacial deformity. Methods A total of 73 patients with dentition defect complicated with dento-maxillofacial deformity admitted to our hospital from June 2022 to January 2025 were selected, and they were divided into the reference group (n =36) and the study group (n =37) according to the random number table method. The reference group received implant restoration, and the study group received orthodontics combined with implant restoration. The restoration effect, dental function, aesthetic effect, plaque attachment index and quality of life were compared between the two groups. Results The excellent and good rate of restoration in the study group (97.30%) was higher than that in the reference group (77.78%) (P <0.05). The scores of masticatory function, swallowing function, dental occlusion and pronunciation function in the study group were higher than those in the reference group (P <0.05). The PES score of the study group after treatment was higher than that of the reference group (P <0.05). The plaque index of the study group after treatment was lower than that of the reference group (P <0.05). The OHIP-14 score of the study group after treatment was lower than that of the reference group (P <0.05). Conclusion The application of orthodontics combined with implant restoration in patients with dentition defect complicated with dento-maxillofacial deformity has a good effect. It can promote the improvement of patients' dental function and aesthetic outcome, help to reduce plaque attachment, and improve their quality of life, which is worthy of clinical application.