Scar tissue is a common product of the natural repair process after skin injury, and its formation mechanism involves a variety of biological processes. Scar not only affects the patient's appearance, but also significantly reduces their quality of life. In current clinical practice, single treatment modalities such as laser therapy or drug therapy have shown good therapeutic effects, but each has certain limitations and is difficult to fully meet the clinical needs of scar treatment. In recent years, the comprehensive scheme of laser combined with drug therapy has gradually attracted attention. This combined treatment strategy exerts the synergistic effect of laser and drugs, intervenes in the scar formation process from multiple pathological links simultaneously, and shows significant advantages in improving scar appearance, texture and functional recovery. This paper aims to systematically review the latest research progress of laser combined with drug therapy in scar treatment, deeply explore its mechanism of action,and provide a comprehensive theoretical basis and innovative treatment ideas for clinical scar treatment.