Facial burn constitutes a distinctive category of injury that, beyond inducing visible disfigurement, is consistently associated with compromised social functioning and demonstrates an elevated incidence of depression relative to the general burn population. Depression may not only delay wound healing and increase pain sensitivity, but also lead to long-term social adjustment disorders such as social avoidance and decreased occupational function, which seriously affect the quality of rehabilitation and life reconstruction. In recent years, growing clinical attention to the mental health problem of facial burn has prompted an expansion of research devoted to the early detection of depressive symptoms through specialized psychological assessment instruments and to the subsequent formulation of multidimensional, individualized psychosocial interventions. This paper systematically reviews the clinical manifestations of depression in patients after facial burn and proposes corresponding intervention measures. The aim is to provide a theoretical basis and practical reference for constructing a more comprehensive and multi-level rehabilitation support system, and ultimately improve patients' quality of life and social integration.