Skin microcirculation is a complex network composed of three major systems: skin microecology, vascular microcirculation, and cellular fiber metabolism. Changes in the structure and function of this network are closely related to the occurrence and development of various skin problems. The three systems interact with each other and operate in coordination to jointly maintain the dynamic balance of skin health. Based on a systematic analysis of the skin microcirculation mechanism, this paper focuses on two major causes of aging (endogenous aging and exogenous aging), explores their specific mechanisms in skin aging in depth, and further proposes effective strategies for intervening in skin aging from three dimensions: antioxidant strategy, promotion of senescent cell repair through active DNA delivery, and avoidance of telomerase-related risks, in order to provide a theoretical reference for clinical practice.