Objective To explore the effect of all-ceramic crown and bridge combined with glass fiber post restoration on masticatory efffciency and aesthetic effect in patients with large area defect of anterior teeth. Methods A total of 82 patients with large area defect of anterior teeth admitted to our hospital from January 2022 to December 2024 were selected, and they were divided into the control group and the observation group according to different restoration plans, with 41 patients in each group. The control group was treated with porcelain crown and bridge combined with cast metal post and core restoration, and the observation group was treated with all-ceramic crown and bridge combined with glass ffber post restoration. The masticatory efffciency, clinical efffcacy, periodontal indicators, gingival crevicular ffuid indicators and aesthetic effect were compared between the two groups. Results The masticatory efffciency of the observation group after treatment was higher than that of the control group (P<0.05). The total effective rate of the observation group (95.12%) was higher than that of the control group (78.05%) (P<0.05). The periodontal indicators and gingival crevicular ffuid indicators of the observation group after treatment were better than those of the control group (P<0.05). The red and white esthetics scores of the observation group after treatment were higher than those of the control group (P<0.05). Conclusion The application of all-ceramic crown and bridge combined with glass ffber post restoration in the treatment of large area defect of anterior teeth has a deffnite clinical effect. It can effectively improve masticatory efffciency and aesthetic effect, optimize periodontal conditions, and reduce gingival crevicular ffuid indicators.