Objective To explore the effect of continuous vacuum sealing drainage technology combined with recombinant bovine basic ffbroblast growth factor (rb-bFGF) irrigation on wound healing in patients with second degree burn. Methods A total of 92 patients with second degree burn admitted to Afffliated Hospital of Guilin Medical University from September 2023 to April 2025 were selected, and they were divided into the control group and the observation group by the random number table method, with 46 patients in each group. The control group received continuous vacuum sealing drainage technology, and the observation group received continuous vacuum sealing drainage technology combined with rb-bFGF irrigation. The pain intensity, clinical efffcacy, wound healing and complication rate were compared between the two groups. Results The VAS score of the observation group after treatment was lower than that of the control group (P<0.05). The total effective rate of the observation group was 95.65%, which was higher than 80.43% of the control group (P<0.05). The VSS score of the observation group after treatment was lower than that of the control group, and the average healing time and average complete eschar dissolution time were shorter than those of the control group (P<0.05). There was no statistically signiffcant difference in the incidence of complications between the two groups (P>0.05). Conclusion In the clinical treatment of patients with second degree burn, the combined application of continuous vacuum sealing drainage technology and rb-bFGF irrigation can effectively reduce patients' pain, improve the overall curative effect, promote wound healing, and has good safety.