Objective To analyze the effect of radiofrequency skin tightening assisted negative pressure liposuction on abdominal contour morphology in patients with abdominal fat accumulation combined with skin laxity. Methods A total of 58 patients with abdominal fat accumulation combined with skin laxity admitted to Shenzhen Jumei Boyue Medical Aesthetic Clinic from October 2022 to October 2024 were selected as the research subjects, and they were divided into the control group and the observation group by the random number table method, with 29 patients in each group. The control group was treated with negative pressure liposuction, and the observation group was treated with radiofrequency skin tightening assisted negative pressure liposuction. The abdominal liposuction volume, abdominal contour morphology, patient satisfaction and physician's satisfaction with the effect were compared between the two groups. Results There was no statistically signiffcant difference in abdominal liposuction volume between the two groups (P>0.05). The abdominal contour morphology grade of the observation group at 6 months after operation was higher than that of the control group (P<0.05). The patient satisfaction of the observation group was 96.55%, which was higher than 75.86% of the control group (P<0.05). The physician's satisfaction with the effect of the observation group was higher than that of the control group (P<0.05). Conclusion For patients with abdominal fat accumulation combined with skin laxity, the treatment of radiofrequency skin tightening combined with negative pressure liposuction can not only effectively improve the abdominal contour morphology and enhance skin tightness, but also has high clinical applicability. This treatment scheme not only improves patients' satisfaction with the curative effect, but also gains the recognition of physicians.