Objective To analyze the effect of operating room systematic nursing on aesthetic effect of wound recovery in burn patients after vacuum sealing drainage. Methods A total of 72 burn patients who received vacuum sealing drainage treatment at Afffliated Hospital of Jiangnan University from January 2021 to January 2025 were selected, and they were divided into the control group and the observation group by the random number table method, with 36 patients in each group. The control group received conventional nursing, and the observation group received operating room systematic nursing. The clinical related indicators, pain status, complication rate and aesthetic effect of wound recovery were compared between the two groups. Results After nursing, the number of dressing changes in the observation group was less than that in the control group, and the wound healing time and hospitalization time were shorter than those in the control group (P<0.05). The pain scores of the observation group at 3, 5 and 10 days after nursing were lower than those of the control group (P<0.05). The incidence of complications in the observation group (2.78%) was lower than that in the control group (16.67%) (P<0.05). The excellent and good rate of the observation group (94.44%) was higher than that of the control group (75.00%) (P<0.05). Conclusion Operating room systematic nursing has comprehensive advantages in the postoperative management of burn patients. It can reduce the number of dressing changes, promote wound healing, shorten hospitalization time, effectively relieve postoperative pain, and reduce the risk of complications. Thus, on the basis of improving treatment efffciency, it further improves the aesthetic effect of wound repair.