Objective To analyze the effect of perioperative comprehensive nursing model on pain status in patients undergoing comprehensive rhinoplasty. Methods A total of 70 patients who underwent comprehensive rhinoplasty in the Department of Plastic Surgery, Jiangsu Province Hospital of Chinese Medicine from July 2021 to June 2024 were selected, and they were divided into the control group and the study group by the random number table method, with 35 patients in each group. The control group received conventional perioperative nursing, and the study group received the perioperative comprehensive nursing model. The psychological and emotional health, psychological resilience, pain status, and surgical related indicators were compared between the two groups. Results After nursing, the scores of SAS and PHQ-9 in the study group were lower than those in the control group (P<0.05). The scores of psychological resilience in the study group after nursing were higher than those in the control group (P<0.05). The scores of VAS in the study group on the 3rd and 5th days after nursing were lower than those in the control group (P<0.05). The nasal tip projection and nasofrontal angle of the study group after nursing were higher than those of the control group, but the differences were not statistically signiffcant (P>0.05). Conclusion The application effect of perioperative comprehensive nursing model in comprehensive rhinoplasty is good. It can not only effectively improve the psychological state and psychological resilience of patients, relieve postoperative pain, but also promote the improvement of key clinical indicators such as nasal tip projection and nasofrontal angle.