Objective: To analyze the impact of fractional laser technology on the Visual Analogue Scale (VAS) score and adverse reactions of patients undergoing facial plastic surgery and aesthetic treatment. Methods: From April 2022 to April 2025, 72 patients with facial plastic and aesthetic surgery who visited the hospital were grouped by random number table method. The conventional group (n=36) was treated with botulinum toxin injection, and the treatment group (n=36) was treated with fractional laser technology. The VAS scores, overall facial cosmetic effect improvement (GAIS) scores, skin indicators, total incidence of adverse reactions, and patient satisfaction of the two groups were compared. Results: Compared with the conventional group, the VAS score of the treatment group was lower after treatment (P < 0.05), and the GAIS score of the treatment group was higher after treatment (P < 0.05). Compared with the conventional group, the skin elasticity and skin moisture after treatment in the treatment group were higher (P < 0.05), while the skin texture and skin wrinkle scores after treatment in the conventional group were lower (P < 0.05). The total incidence of adverse reactions in the treatment group and the conventional group (16.67%, 11.11%) was statistically compared, and there was no difference (P>0.05). Compared with the patient satisfaction rate of the conventional group (72.22%), that of the treatment group (94.44%) was higher (P < 0.05). Conclusion: Fractional laser technology can effectively improve the facial skin condition of patients undergoing facial plastic surgery and aesthetic treatment, enhance patient satisfaction, and no serious adverse reactions have occurred.