Objective To explore the effect of vacuum sealing drainage combined with platelet-rich plasma (PRP) on wound healing quality and aesthetic score in patients with facial trauma. Methods A total of 80 patients with facial trauma admitted to the Department of Burn and Plastic Surgery, Liyang People's Hospital from October 2023 to May 2025 were selected as the research subjects. According to the random number table method, they were divided into the control group and the observation group, with 40 patients in each group. The control group was treated with vacuum sealing drainage, and the observation group was treated with vacuum sealing drainage combined with PRP. The wound healing-related indicators, wound healing quality, aesthetic score and adverse reaction rate were compared between the two groups. Results The wound healing time of the observation group was shorter than that of the control group, and the wound infection rate and scar hyperplasia rate were lower than those of the control group (P<0.05). At 2 months after treatment, the scores of all wound healing quality indicators in the observation group were higher than those in the control group (P<0.05). At 2 months after treatment, the scores of all aesthetic indicators in the observation group were lower than those in the control group (P<0.05). There was no statistically signiffcant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Vacuum sealing drainage combined with PRP in the treatment of facial trauma can shorten wound healing time, reduce the risks of infection and scar hyperplasia, improve wound healing quality and facial aesthetic effect, with favorable safety.