Objective To explore the effect of modified chitin biological adhesive dressing on wound healing time and pain intensity in patients with oral and pharyngeal mucosal wound. Methods A total of 319 patients with oral and pharyngeal mucosal wound admitted to the Department of Stomatology, Dongkeng Hospital of Dongguan from June 2023 to December 2024 were selected as the research subjects. According to the random number table method, they were divided into the control group (159 patients) and the experimental group (160 patients). The control group received conventional treatment, and the experimental group received modiffed chitin biological adhesive dressing. The wound healing time, pain intensity, microenvironment indexes of oral and pharyngeal mucosal wound, clinical efffcacy and adverse reaction rate were compared between the two groups. Results The wound healing time of the experimental group was shorter than that of the control group, and the VAS score was lower than that of the control group (P<0.05). After treatment, the pH value and exudate volume of the oral and pharyngeal mucosal wound in the experimental group were better than those in the control group (P<0.05). The total clinical effective rate of the experimental group was higher than that of the control group (P<0.05). The incidence of adverse reactions in the experimental group was 3.13%, which was lower than 11.95% in the control group (P<0.05). Conclusion Modiffed chitin biological adhesive dressing can effectively construct a favorable microenvironment for the healing of oral and pharyngeal mucosal wounds, promote wound repair, alleviate pain intensity, and achieve deffnite clinical efffcacy with favorable safety.