Objective: To explore the application effect and satisfaction influence of refined nursing intervention in patients undergoing chairside inlay repair with computer-aided design/computer-aided fabrication (CAD/CAM). Methods: From January 2023 to December 2024, 120 eligible patients were randomly assigned to either a control group (n=60, routine nursing) or an observation group (n=60, refined nursing added). The intervention effects of the two groups were compared. Results: The observation group showed significantly higher rates of excellent restoration fit (96.67% vs. 83.33%, P<0.05) and treatment compliance (98.33% vs. 86.67%, P<0.05), greater reduction in OHIP-14 scores (indicating improved oral health-related quality of life), lower complication rate (3.33% vs. 15.00%, P<0.05), and higher nursing satisfaction (96.67% vs. 81.67%, P<0.05) compared with the control group. Conclusion: Refined nursing intervention can enhance the prosthesis suitability and treatment compliance of patients undergoing CAD/CAM chairside inlay restoration, improve the quality of life related to oral health of patients, reduce the incidence of complications, and increase nursing satisfaction. It has high clinical application value.