Objective To explore the effect of problem-guided cognitive-behavioral intervention on quality of life in patients undergoing blepharoptosis correction. Methods A total of 80 patients who underwent blepharoptosis correction admitted to the Department of Plastic Surgery, Jinan Han's Plastic Surgery Hospital from January 2021 to December 2024 were selected as the research subjects. According to the random number table method, they were divided into the control group and the observation group, with 40 patients in each group. The control group received conventional nursing, and the observation group received problem-guided cognitive-behavioral intervention. The coping styles, quality of life and health behaviors were compared between the two groups. Results At 3 months after nursing, the scores of resignation and avoidance in the observation group were lower than those in the control group, while the score of facing was higher than that in the control group (P<0.05). At 3 months after nursing, the scores of all quality of life indicators in the observation group were higher than those in the control group (P<0.05). At 3 months after nursing, the scores of all health behavior indicators in the observation group were higher than those in the control group (P<0.05). Conclusion In the perioperative management of patients undergoing blepharoptosis correction, the application of problem-guided cognitive-behavioral intervention is conducive to promoting the establishment of healthy behavior patterns, improving quality of life, and enhancing the ability to actively cope with the disease.