Objective To comparison of the efficacy and safety of recombinant mussel mucin and recombinant bovine basic fibroblast growth factor gel for wound healing after facial gold microneedle therapy. Methods A total of 40 patients were selected to undergo gold microneedle treatment in our hospital from April to June 2024, and were repaired with recombinant mussel mucin and recombinant bovine alkaline fibroblast growth factor gel after surgery. Recombinant mussel mucin was used on the test side, and recombinant bovine alkaline fibroblast growth factor gel was used on the control side.Clinical assessments, skin examinations, and patient satisfaction evaluations were conducted by physicians, with adverse reactions during treatment documented. Results? The experimental side demonstrated greater alleviation of postoperative symptoms including erythema, edema, burning sensation, and pruritus, with statistically significant differences (P<0.05). The experimental side exhibited more pronounced improvements in red area size and skin smoothness compared to the control side, with statistically significant differences (P<0.05). Patient satisfaction was higher on the experimental side than the control side, with statistically significant differences (P<0.05). Conclusion Recombinant mussel mucin effectively alleviates post-golden microneedling symptoms such as erythema, edema, burning, and itching. It promotes wound healing, helps shorten recovery time, and enhances patient satisfaction, making it worthy of clinical promotion.