Objective: To analyze the clinical efficacy of orthodontics combined with implant denture restoration in the treatment of malocclusion with dentition defect. Methods: Sixty-four patients who received treatment in our hospital from January 2025 to December 2025 were included in the study as observation subjects. Through computer-generated randomization, 32 patients were assigned to the study group and the control group, respectively, and different treatment regimens were administered. The treatment effects were compared. Results: Before treatment, there were no significant differences in alveolar bone height, dental function scores, and soft tissue data indicators between the two groups (p>0.05). After treatment, all patients showed significant improvement. Compared with the control group, the study group patients had superior alveolar bone height data (P<0.05), higher dental function scores (P<0.05), and better soft tissue data (P<0.05). Additionally, the incidence of adverse reactions in the study group was only 3.13%, which was lower than that in the control group (21.88%) (P<0.05). Conclusion: The clinical efficacy of orthodontics combined with implant denture restoration in the treatment of malocclusion with dentition defect is more significant.