Objective To explore the clinical value of minimally invasive tooth extraction combined with simultaneous implantation in the restoration of posterior tooth loss. Methods A total of 80 patients with posterior tooth loss admitted to our hospital from January 2024 to January 2025 were selected, and they were divided into the control group and the observation group by the random number table method, with 40 patients in each group. The control group received delayed implantation restoration after conventional tooth extraction, and the observation group received minimally invasive tooth extraction combined with simultaneous implantation restoration. The implant success rate, peri-implant bone resorption, pain intensity and complications were compared between the two groups. Results The implant success rate of the observation group (95.00%) was higher than that of the control group (82.50%) (P<0.05). At 3 and 6 months after operation, the extent of bone resorption at the mesial, distal, buccal, and lingual (palatal) sites of the implants in the observation group was lower than that in the control group (P<0.05). The VAS scores of the observation group at 24 and 72 hours after operation were lower than those in the control group (P<0.05). The incidence of complications in the observation group (7.50%) was lower than that in the control group (22.50%) (P<0.05). Conclusion Minimally invasive tooth extraction combined with simultaneous implantation has deffnite application value in the restoration of posterior tooth loss, which can reduce the bone resorption of multiple peri-implant sites at different postoperative periods, improve the implant success rate, effectively alleviate postoperative pain, and reduce the risk of complications.