Objective To explore the effect of hand relay ffap in the repair of patients with ffngertip soft tissue defect. Methods A total of 75 patients with ffngertip soft tissue defect diagnosed and treated in the Third Hospital of Baotou from January 2020 to January 2025 were selected, and they were divided into the control group (n=35) and the study group (n=40) according to different treatment methods. The control group was treated with conventional ffap repair, and the study group was treated with hand relay flap repair. The perioperative indicators, overall hand function and complications were compared between the two groups. Results The primary ffap survival rate of the two groups was 100.00%. There were no statistically signiffcant differences in operation time, intraoperative blood loss and wound healing time between the two groups (P>0.05). The Michigan Hand Outcomes Questionnaire (MHQ) scores of the study group at 6 and 12 months after operation were higher than those of the control group (P<0.05). The incidence of complications in the study group (7.50%) was lower than that in the control group (28.57%) (P<0.05). Conclusion Hand relay ffap has a deffnite effect in the repair of ffngertip soft tissue defect, which can improve patients' perioperative indicators, promote the recovery of overall hand function, and reduce the risk of complications. It is worthy of clinical application.