Objective To analyze the application effect of type A botulinum toxin combined with hyaluronic acid in patients undergoing injection rhinoplasty. Methods A total of 120 patients who received rhinoplasty in Nanjing Drum Tower Mylike Medical Cosmetic Clinic from May 2021 to May 2023 were selected, and they were divided into the control group and the study group by the random number table method, with 60 patients in each group. The control group was treated with hyaluronic acid injection rhinoplasty, and the study group was treated with type A botulinum toxin combined with hyaluronic acid injection rhinoplasty. The nasal appearance effect, rhinoplasty satisfaction, material absorption rate and re-rhinoplasty rate were compared between the two groups. Results The scores of nasal tip position, nasal tip shape and nasal dorsum shape in the study group at 12 months after operation were lower than those in the control group (P <0.05). There was no significant difference in the satisfaction of aesthetic appearance and nasal tip projection between the two groups (P >0.05). The material absorption rate of the study group at 12 months after operation was 60.00%, which was lower than 78.33% of the control group (P <0.05). After 2years of follow-up, the re-rhinoplasty rate of the study group was lower than that of the control group (P <0.05). Conclusion The application of type A botulinum toxin combined with hyaluronic acid in injection rhinoplasty is beneficial to improve the nasal appearance, reduce the absorption rate of hyaluronic acid material, prolong the maintenance time of rhinoplasty effect, and improve the satisfaction of patients with rhinoplasty.